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Las células T de los resfriados comunes pueden proporcionar protección contra COVID-19: estudio

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Los altos niveles de células T de los coronavirus del resfriado común pueden proporcionar protección contra COVID-19, según un estudio del Imperial College London publicado el lunes, que podría informar los enfoques para las vacunas de segunda generación.

La inmunidad contra el COVID-19 es un panorama complejo y, si bien hay evidencia de niveles de anticuerpos decrecientes seis meses después de la vacunación, también se cree que las células T desempeñan un papel vital en la protección.

El estudio, que comenzó en septiembre de 2020, analizó los niveles de células T de reacción cruzada generadas por resfriados comunes anteriores en 52 contactos domésticos de casos positivos de COVID-19 poco después de la exposición, para ver si desarrollaron la infección.

Encontró que los 26 que no desarrollaron infección tenían niveles significativamente más altos de esas células T que las personas que sí se infectaron. Imperial no dijo cuánto tiempo duraría la protección de las células T.

«Descubrimos que los altos niveles de células T preexistentes, creadas por el cuerpo cuando se infecta con otros coronavirus humanos como el resfriado común, pueden proteger contra la infección por COVID-19», dijo la autora del estudio, la Dra. Rhia Kundu.

Los autores del estudio, publicado en Nature Communications, dijeron que las proteínas internas del virus SARS-CoV-2 que son el objetivo de las células T podrían ofrecer un objetivo alternativo para los fabricantes de vacunas.

Las vacunas actuales contra la COVID-19 se dirigen a la proteína espiga, que muta regularmente, creando variantes como Omicron que reducen la eficacia de las vacunas contra la infección sintomática.

«En contraste, las proteínas internas a las que se dirigen las células T protectoras que identificamos mutan mucho menos», dijo el profesor Ajit Lalvani, coautor del estudio.

«En consecuencia, están altamente conservados entre las diversas variantes del SARS-CoV-2, incluido Omicron. Las nuevas vacunas que incluyen estas proteínas internas conservadas inducirían respuestas de células T ampliamente protectoras que deberían proteger contra las variantes actuales y futuras del SARS-CoV-2. .»

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